Search results for "carotid arteries occlusion"

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Brain BDNF levels are dependent on cerebrovascular endothelium-derived nitric oxide

2016

International audience; Scientific evidence continues to demonstrate a link between endothelial function and cognition. Besides, several studies have identified a complex interplay between nitric oxide (NO) and brain-derived neurotrophic factor (BDNF), a neurotrophin largely involved in cognition. Therefore, this study investigated the link between cerebral endothelium-derived NO and BDNF signaling. For this purpose, levels of BDNF and the phosphorylated form of endothelial NO synthase at serine 1177 (p-eNOS) were simultaneously measured in the cortex and hippocampus of rats subjected to either bilateral common carotid occlusion (n=6), physical exercise (n=6) or a combination of both (n=6) …

Male0301 basic medicinemedicine.medical_specialtyNitric Oxide Synthase Type IIIEndotheliumHippocampusPhysical exerciseTropomyosin receptor kinase BHippocampusNitric oxide03 medical and health scienceschemistry.chemical_compound0302 clinical medicine[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemphysical exercisenitric oxideNeurotrophic factorsPhysical Conditioning AnimalInternal medicinemedicineAnimalsReceptor trkBRats WistarCerebral CortexBrain-derived neurotrophic factorbiologyChemistry[SCCO.NEUR]Cognitive science/NeuroscienceGeneral Neurosciencebrain-derived neurotrophic factorTrkB[ SDV.MHEP.CSC ] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemRatsCerebrovascular Disorders030104 developmental biologyEndocrinologymedicine.anatomical_structurecarotid arteries occlusionnervous system[ SCCO.NEUR ] Cognitive science/Neurosciencebiology.proteinEndothelium VascularNeuroscience030217 neurology & neurosurgeryNeurotrophinEuropean Journal of Neuroscience

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